Understanding Brain Network Modulation
Dani S. Bassett
May 4, 2023, Thursday, 3:00 PM - 4:00 PM EDT
The human brain is a complex biological system whose function is made possible by a network of structural links along which information can be routed. Understanding structural network constraints is hence key to understanding healthy human brain function and stimulation-based interventions. In this talk, I will canvas recent measurement, modeling, and conceptual expansions that are providing a richer understanding of these structural constraints. As a case study, I will consider evidence that targeting cortical-subcortical structural connections may enhance the impact of TMS on subcortical neural activity and, by extension, subcortex-subserved behaviors, and I will close by describing a computational approach (network control theory) to model structural predictors of brain dynamics elicited by stimulation.
Dani S. Bassett is the J. Peter Skirkanich Professor in the Departments of Bioengineering, Electrical & Systems Engineering, Physics & Astronomy, Neurology, and Psychiatry. They are also an external professor of the Santa Fe Institute. Their work blends neural and systems engineering to excavate mechanisms of cognition and disease in human brain networks.